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针对肺 Mycobacterium avium 复杂疾病阶段诊断的抗原特异性细胞因子概况

Yoshiro Yamashita^1,2, Ikkoh Yasuda^1,3, Takeshi Tanaka⁴

¹Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Nagasaki, Japan.

Frontiers in immunology

|July 31, 2023

概括

诊断肺部Mycobacterium avium复合体 (MAC) 疾病阶段是一个挑战. 这项研究揭示了CD4+T和CD19+B细胞中不同的细胞因子概况,可以帮助识别MAC的临床阶段.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
呼吸系统医学呼吸系统医学

背景情况:

肺部Mycobacterium avium复合体 (MAC) 疾病的诊断受到无法准确确定临床阶段的困扰.
目前的诊断方法缺乏有效的生物标志物来评估疾病进展和治疗反应.

研究的目的:

在MAC的不同临床阶段识别Mycobacterium avium抗原的CD4+T和CD19+B细胞的细胞因子特征.
探索细胞介导免疫作为MAC分期的诊断工具的潜力.

主要方法:

招募了47名MAC患者 (治疗前,治疗期间和治疗后) 和17名健康对照.
培养的外周血液单核细胞具有特定的Mycobacterium avium抗原.
通过流式细胞计量分析了CD4+和CD19+细胞的细胞因子 (IFN-γ,TNF-α,IL-2,IL-10,IL-17) 概况.

主要成果:

与治疗前和对照组相比,Th1细胞因子 (IFN-γ,TNF-α) 在治疗期间和治疗后的组显著增加.
IL-2的存在与治疗后的阶段相关,这表明它在记忆功能中的作用.
非Th1细胞因子 (IL-10,IL-17) 在治疗前组显示出更高的反应.

结论:

独特的细胞因子概况为肺性MAC的每个临床阶段提供了特征.
对CD4+T和CD19+B细胞的细胞因子分析为MAC患者的分期提供了潜力.

关键词:

在CD19+B细胞中.在CD4+T细胞中.菌复杂性疾病 (Mycobacterium avium) 是一种复杂的疾病.这是一种与Mycobacterium avium相关的抗原.通过细胞介导的免疫.临床阶段临床阶段细胞因子概况细胞因子概况

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