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Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
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A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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基于参数的4D剂量计算用于质子疗法.

Franciska Lebbink1,2, Silvia Stocchiero1,2, Piero Fossati2,3

  • 1Medical University of Vienna, Department of Radiation Oncology, Vienna, Austria.

Physics and imaging in radiation oncology
|July 31, 2023
PubMed
概括
此摘要是机器生成的。

一个新的前性工具准确地预测了质子疗法中的运动灵敏度. 这种基于参数的4D剂量计算 (p-4DDC) 方法可以指导癌症患者的治疗计划和运动缓解策略.

关键词:
4D 4D是什么意思剂量计算 剂量计算互动 互动 互动肝脏和胰腺癌的癌症.测量方法 测量方法笔光束扫描扫描的使用.质子疗法是一种质子疗法.

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科学领域:

  • 医学物理 医学物理
  • 辐射瘤学 辐射瘤学
  • 计算生物学 计算生物学

背景情况:

  • 追溯日志文件分析估计了质子疗法中提供的剂量,但缺乏前性预测.
  • 预测患者特定的运动敏感性需要在治疗开始前实施一个工具.
  • 开发和评估了一种基于参数的新型工具,用于前四维剂量计算 (4DDC).

研究的目的:

  • 调查基于参数的4DDC (p-4DDC) 方法,用于预测扫描脉冲质子束治疗中的运动灵敏度.
  • 通过对测量和基于日志文件的4DDC工具对人类形象幻象和患者数据进行验证p-4DDC方法.
  • 评估呼吸运动对有风险的目标和器官剂量体积组图参数的影响.

主要方法:

  • 对七名癌症患者进行了4DDC,他们接受了扫描脉冲质子束疗法,并进行了小呼吸运动.
  • 根据测量数据和基于日志文件的4DDC工具验证了p-4DDC方法.
  • 分析了目标体积和有风险的器官的剂量-体积组图参数,比较了静态,基于日志文件和p-4DDC的结果.

主要成果:

  • 通过p-4DDC方法,在测量偏差范围内 (最大0.4 Gy) 证明了剂量预测的准确性.
  • 对于规划目标量,p-4DDC和日志文件的结果达成2%的一致,与静态计算相比,变化高达15%.
  • 对于肝脏和胰腺患者,p-4DDC与基于日志文件的4DDC相比分别显示了10%和11%的偏差.

结论:

  • 基于参数的4D剂量计算 (p-4DDC) 方法适合在临床环境中前性使用.
  • p-4DDC工具可以帮助调整治疗计划或实施运动减轻策略.
  • 临床实施p-4DDC工具是提高质子治疗精度的下一个逻辑步骤.