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Updated: Jul 20, 2025

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鉴定一种基于伊米达索皮里丁的化合物作为口服选择性雌激素受体降解剂,用于乳腺癌治疗

Mengwu Pan1, Valeria Solozobova1, Nane C Kuznik1

  • 1Institute of Biological and Chemical Systems - Biological Information Processing, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany.

Cancer research communications
|July 31, 2023
PubMed
概括

一种新型的伊米达索皮里丁化合物X15695有效降解雌激素受体α (ERα) 并抑制ER阳性乳腺癌的生长. 这种口服药物还会重新激活p53,导致细胞亡和潜在的新乳腺癌疗法.

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