一种I型糖尿病患者的糖尿病酸性酸症,该患者接受了闭环传感器增强胰岛素输液系统的治疗
Pranjali P Sharma1, Ana M Ramirez-Berlioz1, Angela D Weisz2
1Department of Endocrinology, Parkview Health System, Pueblo, Colorado.
AACE clinical case reports
|July 31, 2023
概括
蒂尔泽帕提德可以导致体积耗尽,导致闭环系统 (CLS) 失效和糖尿病酸性糖尿病 (DKA) 在1型糖尿病中. 使用CLS的患者应该意识到这一风险,并与医生讨论备用计划.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病 技术 技术
背景情况:
- 闭环胰岛素输液系统 (CLS) 改善了1型糖尿病 (T1DM) 的血糖控制.
- 提尔泽帕提德用于减肥,但可能导致体积耗尽.
研究的目的:
- 报告由于蒂尔泽帕提德诱导的体积耗尽而导致的CLS失效的情况.
- 要突出使用CLS的T1DM患者糖尿病酸性酸症 (DKA) 的风险.
主要方法:
- 一个36岁的T1DM妇女在Tandem t:slim与控制IQ (t:slim CIQ) CLS上的病例报告.
- 在DKA的发作期间分析临床表现,实验室结果和持续血糖监测 (CGM) 数据.
- 停止提泽帕提德和CLS管理调整.
主要成果:
- 患者在使用提尔泽帕提德后,尽管高血糖 (322 mg/dL),但同时出现低CGM读数 (40 mg/dL) 的DKA.
- 通过静脉注射液体和胰岛素解决了DKA,在停止治疗蒂尔泽帕蒂德后,CLS/CGM成功恢复.
- 卷积耗尽被确定为CLS失效的可能原因.
结论:
- 体积耗尽可以改变间歇性葡萄糖水平,导致T1DM患者的CLS衰竭和DKA.
- 应提醒CLS患者注意在体积减弱状态下潜在的CLS衰竭.
- 讨论备用计划,如每天多次注射胰岛素,对于使用CLS的患者至关重要.
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