在狭窄性克罗恩型结肠炎中,在炎症前部位的光滑肌肉功能障碍:机械应激对肠道功能障碍在肠道炎症中的影响
John C Johnson1,2, Ramasatyaveni Geesala1, Ke Zhang1
1Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX, United States.
Frontiers in physiology
|July 31, 2023
概括
由于炎症诱导的狭窄引起的机械压力会损害克罗恩氏类结肠炎中肠道光滑肌功能. 肠道营养和COX-2抑制通过减少机械应激和炎症来改善平滑肌肉收缩性.
科学领域:
- 胃肠病学 胃肠病学
- 身体生理学 身体生理学
- 炎症研究 炎症研究
背景情况:
- 肠道光滑肌肉功能障碍有助于IBD症状,如和改变肠道习惯.
- 与IBD相关的光滑肌肉功能障碍背后的机制尚不清楚.
- 结肠狭窄引起的机械压力可能会影响克罗恩氏状结肠炎的光滑肌功能.
研究的目的:
- 为了研究机械应激在光滑肌肉功能障碍中的作用,在克罗恩氏类结肠炎的老鼠模型中.
- 为了确定炎症性狭窄和随后的膨胀对结肠光滑肌肉收缩性的影响.
- 评估排他性肠道营养和COX-2抑制的治疗潜力.
主要方法:
- 在斯普拉格-道利大鼠中通过TNBS灌注诱导的克罗恩样结肠炎.
- 老鼠可以接受定期的固体饮食或完全的液体饮食.
- 评估了光滑肌肉收缩性,COX-2表达和PGE2产生.
主要成果:
- TNBS治疗导致狭窄和膨胀,抑制光滑肌肉收缩性,并在炎症和预炎症部位增加COX-2/PGE2.
- 液体饮食使张正常化,减少了COX-2/PGE2,并改善了光滑肌肉功能.
- NS-398 (COX-2 抑制剂) 在预炎和炎症部位恢复了收缩能力.
结论:
- 结肠平滑肌肉在狭窄性克罗恩氏类结肠炎中受损,影响着炎症和膨胀的区域.
- 机械压力诱导的COX-2表达是光滑肌肉功能障碍的一个关键因素.
- 肠道营养和COX-2抑制显示出治疗IBD相关的光滑肌肉功能障碍的前景.
更多相关视频
09:44Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
Published on: September 11, 2012
22.2K
09:04DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
47.6K
相关概念视频
01:30Inflammatory Bowel Disease II: Crohn's Disease
293
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
293
01:17Chronic Bowel Disorders: Introduction
485
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
485
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
215
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
215
01:17Gastritis-II: Pathophysiology
376
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
376
01:21Inflammatory Bowel Disease V: Surgical Management
170
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
170
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
355
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
355