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在北极地松鼠的冬眠季节,非的热生成受差异调节
Moriah Hunstiger1, Michelle Marie Johannsen1,2, S Ryan Oliver1
1Department of Chemistry and Biochemistry, University of Alaska Fairbanks, Fairbanks, AK, United States.
Frontiers in physiology
|July 31, 2023
概括
北极地松鼠在冬眠期间通过不同的热生成途径调节体温. 棕色脂肪组织和肌肉中的蛋白质表达因季节性变化而变化,有助于在寒冷时期的生存.
科学领域:
- 生理学 生理学 生理学
- 冬眠生物学 冬眠生物学
- 哺乳动物的温度调节
背景情况:
- 北极地松鼠在冬眠期间经历了极端的生理变化.
- 在从冬眠中唤醒时,保持稳定的体温 (热生成) 是至关重要的.
研究的目的:
- 研究与北极地松鼠温度调节相关的季节性蛋白质表达模式.
- 了解特定蛋白质在冬眠期间的非发热生成中的作用.
主要方法:
- 在9个月的时间里采集了组织样本 (延伸指长长,腹膜,棕色和白色脂肪组织).
- 西方斑点评估了蛋白质表达,血液分析了代谢物.
- 分析了与冬眠周期和季节性变化有关的蛋白质表达.
主要成果:
- 解蛋白1在冬季达到棕色脂肪组织的峰值,而不是白色脂肪组织.
- 在腹膜和延伸长肌 (extensor digitorum longus) 肌肉中的 ATPase (SERCA) 表达式显示出季节性变化.
- 在隔膜组织中发现了热源性解剂萨尔科利宾,并在冬眠期间减少.
结论:
- 热生成蛋白的明确季节性调节表明它们在维持体温方面有不同的作用.
- 不发的热生成途径根据冬眠状态和环境因素被差异地利用.
- 了解这些机制对于理解哺乳动物适应极端环境至关重要.
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