由于心脏和肝脏的铁沉积而导致的甲状腺弹性变化
Noor Mohammad Noori1, Alireza Teimouri2
1Children and Adolescents Health research center, Research Institute of cellular and Molecular Science in Infectious Diseases , Zahedan University of Medical Sciences, Zahedan, Iran.
Caspian journal of internal medicine
|July 31, 2023
概括
患有thalassemia的儿童的铁过载显著影响大动脉弹性和心脏功能. 高水平的费里与心脏的铁沉积相关,突出显示了像MRI T2*这样的先进成像学的需要.
科学领域:
- 心脏病学 心脏病学
- 儿科 儿科 儿科
- 放射学 放射学是一门学科.
背景情况:
- 铁过载是thalassemia患者的重要并发症,导致心脏功能障碍.
- 这项研究调查了由于铁沉积而导致的甲状腺弹性的变化.
研究的目的:
- 评估铁过载对患有thalassemia的儿童大动脉弹性的影响.
- 为了将费里水平与心脏和肝脏的铁沉积相关联.
主要方法:
- 一项病例对照研究,涉及160名血病患者和80名健康对照.
- 用心声和MRI T2*来测量心脏和肝脏的铁沉积和大动脉弹性参数.
- 使用SPSS进行了统计分析,p < 0.05被认为是显著的.
主要成果:
- 与对照人群相比,thalassemia患者的透静血压,大动脉尺寸,费里水平,大动脉应变,大动脉延伸性,压力应变弹性模量和大动脉刚度β指数发生了显著的变化.
- 大动脉直径 (AoD),大动脉缩直径 (AoS),费里丁,大动脉应变 (AS) 和大动脉延伸性 (AD) 在血病患者中增加.
- 在患有心脏铁沉积异常的血病患者中,费里丁水平显著更高.
结论:
- 大动脉尺寸和弹性参数因铁过载而改变在患有thalassemia的儿童中.
- 这些患者的费里水平表明心脏的铁沉积,但不是肝脏的铁沉积.
- 推MRI T2*用于评估心脏和肝脏功能在血病患者.
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