血清费里丁与儿科输血依赖性沙拉西米亚的生长状态之间的关系
Andi Cahyadi1, I Dewa Gede Ugrasena1, Mia Ratwita Andarsini1
1Department of Child Health, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, East Java, Indonesia.
Caspian journal of internal medicine
|July 31, 2023
概括
儿科输血依赖性沙拉西米亚 (TDT) 的增长迟缓与高费里水平和特定的铁化治疗有关. 上半身段缩短和身高受影响最大,突出了优化TDT管理的需要.
科学领域:
- 儿科血液学 儿科血液学
- 内分泌学 在内分泌学.
- 增长和发展 增长和发展
背景情况:
- 增长迟缓,以矮身和上肢缩短为特征,是儿科输血依赖性沙拉西米亚 (TDTs) 的显著长期并发症.
- 这种情况是由多因素引起的,包括慢性缺氧,铁过载,内分泌病,不充分的输血和铁化疗法.
- 了解铁过载对生长的影响对于管理TDT患者至关重要.
研究的目的:
- 分析TDT的儿科患者血清费里丁水平和各种生长参数之间的关系.
- 为了比较经过不同铁化疗程的TDT患者的生长状态.
主要方法:
- 进行了一项涉及2-18岁儿科TDT患者的横截面研究.
- 使用CDC的生长图表评估了生长参数,包括上/下体段比率,体重与年龄之间的Z分数 (WAZ),身高与年龄之间的Z分数 (HAZ) 和BMI的Z分数.
- 血清费里丁水平被监测,并进行统计分析 (斯皮尔曼相关性,曼-惠特尼U测试) 来评估相关性.
主要成果:
- 血清费里丁与上/下体段比率 (rho=-0.552;P=0.002) 有显著的负相关性,但与HAZ,WAZ或BMI Z-score没有显著的负相关性.
- 血清费里丁水平超过2500μ/L的患者中,增长迟缓更为明显.
- 与deferasirox治疗的患者相比,接受deferasirox治疗的患者表现出较低的WAZ和BMIZ分数,以及较高的上/下体段比率.
结论:
- 高水平的费里和deferiprone治疗与儿科TDT中更明显的增长迟缓有关.
- 身高和上/下体段比率是这个群体中特别受影响的生长参数.
- 这些发现强调了对铁水平的警监测和对化策略的考虑在管理儿科TDT增长中的重要性.
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