开发和验证用于预测腹膜透析相关腹膜炎患者的阴性细菌感染的诺米克图
Guiling Liu1,2, Xunliang Li1,2, Wenman Zhao1,2
1Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Heliyon
|July 31, 2023
概括
一种新的名图可以预测腹膜透析相关腹膜炎 (PDAP) 患者的グラム阴性细菌 (GNB) 感染. 该工具有助于识别高风险个体,以便及时进行干预,并改善PDAP患者的治疗结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
- 医疗信息学 医疗信息学
背景情况:
- 腹膜透析相关的腹膜炎 (PDAP) 是一个常见的并发症.
- 格拉姆阴性细菌 (GNB) 感染对PDAP患者构成重大风险.
- 在PDAP中准确预测GNB感染对于有效管理至关重要.
研究的目的:
- 开发和验证PDAP患者GNB感染的预测性名录.
- 确定与该人口中GNB感染相关的关键临床和生化因素.
- 加强在PDAP中GNB的早期发现和管理策略.
主要方法:
- 从2016年1月到2021年12月的PDAP患者数据的回顾性分析.
- 利用后勤回归,LASSO和随机森林算法来识别预测因素.
- 将显著因素集成到多变量逻辑回归模型中,并构建了一个名ogram.
主要成果:
- 最终的队列包括217名PDAP患者,其中17.1%患有GNB感染.
- 年龄,前素和血红蛋白被确定为GNB感染的独立预测因素.
- 诺米图表显示出良好的预测准确性,C指数为0.821和AUC为0.821.
结论:
- 为预测PDAP患者的GNB感染而开发了一种新型的诺米克图.
- 诺米图显示出高临床效用和预测准确度.
- 这种工具可以帮助早期识别GNB感染,促进及时治疗并改善患者的预后.
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