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Updated: Jul 20, 2025

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
07:49

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling

Published on: August 3, 2018

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miR-145通过ADAM17介导的ACE2脱落缓解了光滑肌肉细胞表型过渡

Juan Wen1, Baiyi Tang1, Lan Guo1

  • 1Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha 410013, China.

International journal of hypertension
|July 31, 2023
PubMed
概括

在代谢性高血压中,microRNA-145 (miR-145) 有助于防止血管光滑肌细胞 (VSMC) 过渡. 它通过调节ADAM17介导的ACE2分泌和ACE2-Ang-(1-7) -Mas受体轴来起作用,有利于血管重塑.

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Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

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相关概念视频

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Cell Motility through Blebbing

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Blebbing Through the Matrix
In multicellular...
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Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

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Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
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