一个臭名昭著的三重奏! 炎症,代谢综合征和白风
Amany I Mustafa1, Ahmed M Hamed1, Ahmed S Kadah2
1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Benha University, Cairo, Egypt.
Indian dermatology online journal
|July 31, 2023
概括
代谢综合征 (MS) 在白风患者中更为普遍,表明有系统性联系. 像FABP4和hs-CRP这样的高生物标志物可能有助于预测白风患者的MS风险.
科学领域:
- 皮肤病学 皮肤病学
- 内分泌学 在内分泌学.
- 临床生物化学 临床生物化学
背景情况:
- Vitiligo 是一种全身性自身免疫性疾病,它与代谢综合征 (MS) 有潜在的联系.
- 连接白风和MS的精确致病机制在很大程度上仍未被阐明.
- 了解这种关联对于对患者护理的整体方法至关重要.
研究的目的:
- 调查白风和代谢综合征之间的关联.
- 评估特定的炎症生物标志物,以预测白风患者的MS风险.
- 探索血清标记在评估白风中MS并发症中的有用性.
主要方法:
- 一个病例控制研究,涉及100名白风患者和100名年龄,性别和BMI匹配的对照.
- 对所有参与者的代谢综合征成分的评估.
- 测量了来自内脏脂肪组织的血清水平 血清蛋白酶抑制剂 (vaspin),脂肪酸结合蛋白4 (FABP4),血管粘附蛋白1 (VAP-1),奇丁酶-3样蛋白1 (YKL-40) 和高灵敏性C反应蛋白 (hs-CRP).
主要成果:
- 代谢综合征在白风患者 (22.0%) 与对照组相比 (2.0%,P < 0.001) 显著更常见.
- 在白病患者和对照患者中观察到FABP4,VAP-1,YKL-40和hs-CRP的血清水平升高 (P <0.05).
- 这些生物标志物在预测多发性硬化症方面表现出高灵敏度和特异性,与脂质谱和禁食血糖相关.
结论:
- 代谢综合征与白风有显著的关联,强调其系统性影响.
- 升高的生物标志物 (FABP4,VAP-1,YKL-40,hs-CRP) 可以准确预测白风患者的MS.
- 这些标志物显示出在白风中评估多发性硬化症风险的潜力,需要进一步进行广泛的研究.
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