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Updated: Jul 20, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

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作为抗扩散剂的结构相关库马林衍生物的合成

Ezequiel F Bruna-Haupt1,2, Marcelle D Perretti3, Hugo A Garro1,2,4,5

  • 1Department of Chemistry, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, San Luis 5700, Argentina.

ACS omega
|July 31, 2023
PubMed
概括

研究人员合成了35种库马林衍生物,以发现新的抗增殖剂. 两种衍生品显示出显著的抗聚合酶活性,而另一种则显示出对瘤细胞系的强有力的抗癌作用. 某些氨酸还诱导DNA损伤,并表现出抗逆转录病毒性质.

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