库尔库明微球的双阶段超分子自组装导向的原蛋白-质装饰的脂质体复合体,具有增强的溶解性和生物可用性
Maria Jose Louis1, Abhilash Balakrishnan1, Ashil Joseph1
1R&D Centre, Akay Natural Ingredients, Cochin, Kerala 683561, India.
ACS omega
|July 31, 2023
概括
原蛋白可以为口服库尔库明提供"绿色"配方,显著提高其溶解性和生物可用性. 这种新的方法提高了营养吸收,改善了健康结果.
科学领域:
- 营养科学 营养科学
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
背景情况:
- 植物营养素的提高溶解度和生物可用性对于有效的营养疗法至关重要.
- 发展 发展 发展 发展
- 绿色 绿色 绿色 绿色 绿色
- 植物营养素的口服输送系统仍然是一个重大挑战.
研究的目的:
- 研究原作为一种功能性剂,用于装饰和稳定脂质体,用于口服植物营养素输送.
- 为了发展一个
- 绿色 绿色 绿色 绿色 绿色
- 库尔库的脂质体配方,可改善溶解性和生物可用性.
主要方法:
- 采用了两阶段的超分子自我组装过程,以创建原装饰的脂质体黄素 (CCL) 复合体.
- 用光谱学研究 (UV-vis,光,FTIR,循环二重化) 来分析分子自我组装和相互作用.
- 药物动力学分析是通过使用UPLC-ESI-MS/MS的随机双盲对照试验对健康志愿者进行的.
主要成果:
- 在CCL微球中,黄素的可溶性和持续释放性质增加了1.46×105倍.
- 光谱数据证实了原蛋白在脂质双层周围的自我组装,形成了黄素封装的矩阵.
- 与对照组相比,口服CCL显著提高了黄素的血度 (AUC0-12h增加53倍),消除半衰期和整体生物利用性.
结论:
- 原蛋白是一种安全,天然和有效的代理,用于创建稳定,有效的原蛋白.
- 绿色 绿色 绿色 绿色 绿色
- 脂质体配方用于口服植物营养素输送.
- 开发的CCL配方为提高黄素生物利用率和治疗疗效提供了一个有希望的策略.
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