新开发的气体辅助声动疗法用于癌症治疗
Meng Pan1, Danrong Hu1,2, Liping Yuan1
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
Acta pharmaceutica Sinica. B
|July 31, 2023
概括
超声波疗法 (SDT) 通过使用超声波来激活敏感器来增强癌症治疗,从而产生反应性氧物种 (ROS) 来杀死瘤细胞. 气体辅助SDT策略显示出提高效率和未来临床应用的前景.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
- 光动力学疗法 光动力学疗法
背景情况:
- 声动疗 (SDT) 是一种非侵入性疗法,使用超声波来激活通过活性氧物种 (ROS) 激活瘤细胞破坏敏感剂.
- 目前的SDT抗癌疗效是有限的,尽管它的瘤特异性和深层组织透.
- 气体辅助疗法是一种提高SDT有效性的新策略.
研究的目的:
- 总结SDT和气体辅助SDT的机制.
- 审查气体辅助SDT在癌症治疗中的应用,按气体类型分类.
- 在SDT期间展示实时成像治疗系统,并讨论未来的临床挑战和前景.
主要方法:
- 关于SDT和气体辅助SDT机制的文献综述.
- 按气体类型对气体辅助SDT应用进行分类.
- 综合成像和治疗系统的介绍.
主要成果:
- 阐明了SDT和气体辅助SDT的机制.
- 在临床前癌症模型中探索了各种气体类型,以提高SDT的疗效.
- 讨论了具有实时成像能力的SDT系统.
结论:
- 气体辅助SDT提供了一个有前途的策略,以提高抗癌疗效.
- 需要进一步的研究和开发,以应对临床翻译的挑战.
- 整合成像与气体辅助SDT具有精确癌症治疗的潜力.
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