周围状腺细胞复合体厚度降低 - - 在使用基洛昆的患者中,黄斑损伤的第一个迹象
Sümeyye Burcu Elpeze Agcayazi1, Vuslat Gurlu2, Goksu Alacamli3
1Ophthalmology Department, Istanbul Training and Research Hospital, Istanbul, Turkey.
Romanian journal of ophthalmology
|July 31, 2023
概括
光学连贯断层扫描 (OCT) 可以通过在临床症状出现之前测量减少的干细胞复合体 (GCC) 厚度来检测早期氧化 (HCQ) 黄斑病变,从而有助于早期诊断.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 毒理学 毒理学 毒理学
背景情况:
- 氧化 (HCQ) 用于自身免疫性疾病.
- HCQ可能会导致黄斑病,严重的视力障碍.
- 早期检测HCQ黄斑病变对于保护视力至关重要.
研究的目的:
- 在接受HCQ的患者中,使用光学连贯性断层扫描 (OCT) 评估质细胞复合体 (GCC) 厚度.
- 在结构或功能变化明显之前识别HCQ黄斑病的早期迹象.
- 评估OCT在早期诊断HCQ诱导的黄斑病的有用性.
主要方法:
- 研究了40名HCQ患者的80只眼睛 (第一组) 和20名健康对照者的40只眼睛 (第二组).
- 进行了光谱域OCT,视野 (VF) 和彩色视觉测试.
- 测量包括斑点厚度,GCC厚度和周状视网膜神经纤维层 (RNFL) 厚度;已有视网膜变化的患者被排除在外.
主要成果:
- 与对照组相比,HCQ患者的周周GCC厚度明显较薄 (p<0.017).
- 在HCQ组中,平均全球下半球和鼻象限RNFL厚度也减少了 (p<0.012).
- 这些变化检测到在没有临床征兆的黄斑病症.
结论:
- 由OCT检测到的减少的GCC和RNFL厚度表明早期的HCQ巨病.
- 海洋和海上国家/地区的测量可以作为早期检测HCQ毒性的诊断辅助.
- 这种方法可以在临床症状出现之前进行诊断,从而能够及时干预.
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