癌症对中风复发和死亡率的影响:一个单中心的回顾性队列研究
Kang-Po Lee1,2, Hui-Chi Huang3, Jui-Yao Tsai3
1Department of Neurology, E-Da Hospital, Kaohsiung, Taiwan.
eNeurologicalSci
|July 31, 2023
概括
与癌症不活跃或没有癌症患者相比,活跃癌症和中风患者面临的死亡率和复发风险明显更高. 这凸显了活跃癌症对中风结果的关键影响.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 患有中风和癌症的患者的特定特征尚未得到很好的定义.
- 关于个体癌症类型如何影响中风结果的研究有限.
- 了解这些关联对于患者的管理和预后至关重要.
研究的目的:
- 调查中风和伴随癌症患者的死亡率和中风复发率.
- 在这个患者群体中确定预测结果的预测因素.
- 为了比较不同癌症状态 (活跃,不活跃,没有) 的结果.
主要方法:
- 从一家医院中风登记处回顾录取1868名患者 (2019年1月 - 2020年12月).
- 分类为与癌症相关的中风 (CAS),不活跃癌症的中风和没有癌症的中风.
- 出院和1年死亡率和中风复发率的比较,以及临床特征和并发症.
主要成果:
- 16.2%的患者患有并发癌症;2.1%患有CAS,14.1%患有与非活跃癌症相关的中风.
- 与非活性癌症 (12.5%,33.8%) 和没有癌症 (4.7%,12.4%) 组相比,CAS患者的30天 (17.9%) 和1年 (51.3%) 死亡率显著更高.
- 在CAS组中,中风复发率也大幅增加.
结论:
- 患有活跃癌症和中风的患者经历了类似的中风严重程度,但1年死亡率和中风复发率明显较高.
- 这些结果比患有不活跃癌症或没有癌症的患者要糟糕.
- 活跃的癌症状态是中风后不良结果的重要决定因素.
相关概念视频
01:21Cancer Survival Analysis
384
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
384
02:40Cancer Stem Cells and Tumor Maintenance
5.0K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
01:22Cardiac Output II: Effect of Stroke Volume on Cardiac Output
1.1K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
1.1K
01:27Regulation of Stroke Volume
3.3K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
3.3K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
02:18Cancer
48.7K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.7K