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直接作用的抗病毒治疗对于患有精神疾病的慢性HCV患者是安全有效的
Hiroshi Okano1, Takanori Takenaka1, Hiroki Asakawa1
1Department of Gastroenterology, Suzuka General Hospital, Suzuka, Mie 513-8630, Japan.
Experimental and therapeutic medicine
|July 31, 2023
概括
直接作用的抗病毒疗法对患有型肝炎病毒 (HCV) 感染的患者有效且安全,包括患有精神疾病的患者. 这些治疗方法为所有HCV患者提供了显著的好处,可以预防严重的肝病.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 型肝炎病毒 (HCV) 感染可用直接作用抗病毒药物 (DAA) 治疗.
- 在患有精神疾病的HCV患者中,DAA的疗效和安全性尚未得到充分证实.
- 精神病的并发症可能会影响慢性HCV感染的治疗结果.
研究的目的:
- 为了比较DAA治疗在患有或没有精神疾病的HCV患者的疗效和安全性.
- 在这些患者群体中评估持续病毒学响应 (SVR) 率.
- 评估与HCV精神病患者的DAA的耐受性.
主要方法:
- 回顾性,单中心的观察性研究.
- 数据收集于2014年9月至2021年12月期间在日本苏州总医院.
- 统计分析包括费舍尔的精确测试,曼-惠特尼U测试和弗里德曼的测试.
主要成果:
- 15名患有精神疾病 (P) 的HCV患者和209名没有 (NP) 的患者接受了DAA治疗.
- 在P组中,SVR率为80%,在NP组中为90%,没有显著差异.
- 两组之间没有观察到实验室数据或与治疗相关的不良事件的显著差异.
结论:
- 在患有精神疾病的HCV患者中,DAA治疗是有效的,安全的,并且耐受良好.
- 患有HCV的精神病患者应接受DAA治疗,以预防肝病的进展.
- 对于HCV患者来说,DAA无论精神病状况如何,都提供了可比的结果.
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