难以治疗的抑郁症 难以治疗的抑郁症 范围审查 范围审查
Walter Paganin1, Sabrina Signorini2, Antonio Sciarretta3
1Psychiatrist-Psychotherapist-PhD Student in Neuroscience, Tor Vergata University, Rome, Italy, EU.
Clinical neuropsychiatry
|July 31, 2023
概括
难以治疗的抑郁症 (DTD) 是一个独特的临床概念,它扩展了耐治疗抑郁症 (TRD). 本综述总结了目前的理解,并强调了对DTD病理生理学和治疗的进一步研究的需要.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 难以治疗的抑郁症 (DTD) 越来越多地被认为是一种独特的临床实体.
- 现有的DTD定义,如2020年共识声明,将其描述为抑郁症,尽管标准治疗努力,但导致重大负担.
- 对DTD的干预需要全面的方法,不仅要解决症状控制,还要解决并发症,心理社会功能和自我管理.
研究的目的:
- 进行关于难以治疗抑郁症的病理生理学和治疗的科学文献的范围审查.
- 澄清目前对DTD的概念化及其与耐治疗抑郁症 (TRD) 的区别.
- 识别关于DTD现有的知识体系中的贡献,概念,理论和差距.
主要方法:
- 在主要的数据库中进行了系统的文献搜索:PubMed,Scopus,PsycINFO,Cochrane图书馆和Open Grey.
- 搜索的重点是2013年1月1日至2023年3月1日之间发表的与难以治疗的抑郁症相关的文章.
- 两位研究人员使用正式的检查清单独立评估了资格标准,并对综合性文章进行了进一步的数据评估.
主要成果:
- 审查发现了一系列文献,提供了更清晰的难以治疗抑郁症的定义.
- 这些发现为DTD的临床应用和研究前景提供了洞察力.
- 文献支持DTD作为复杂抑郁综合征的理论和临床有用概念化.
结论:
- 难以治疗的抑郁症代表了一个重要的概念转变,扩展了治疗耐药性抑郁症的模型.
- DTD为临床医生和研究人员提供了评估和干预的最新标准,专注于更广泛的治疗反应.
- 需要进一步的研究,包括随机对照试验和观察性研究,以完全定义和调查DTD.
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