荷尔蒙避孕药暴露与前带皮层和杏仁体休息状态功能连接的变化有关
Esmeralda Hidalgo-Lopez1,2, Isabel Noachtar1,2, Belinda Pletzer1,2
1Centre for Cognitive Neuroscience, University of Salzburg, Salzburg, Austria.
Frontiers in endocrinology
|July 31, 2023
概括
在女性中,较长时间使用荷尔蒙避孕药 (HC) 与像杏仁体和前带皮层 (ACC) 这样的大脑区域的功能连接性降低有关. 这种效应不论是孕激素类型都被观察到,尽管孕激素的雄激素性影响了灰质体积和特定的连接模式.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 放射学 放射学是一门学科.
背景情况:
- 激素避孕药 (HCs) 广泛使用,并改变内源性卵巢激素,影响大脑可塑性.
- 前带状皮质 (ACC) 和杏仁体是表达类固醇受体的关键大脑区域,表现出荷尔蒙状态依赖的功能.
- 以前的研究表明,基于荷尔蒙状况和HC使用,ACC和杏仁体的功能差异.
研究的目的:
- 调查使用荷尔蒙避孕药 (HC) 持续时间与ACC与杏仁体之间的休息状态功能连接 (rs-FC) 之间的关系.
- 为了检查孕激素对这些大脑连接模式的androgenicity的影响.
- 评估HC使用时间和ACC和杏仁体灰质体积之间的关联.
主要方法:
- 对231名健康年轻女性休息状态功能磁共振成像 (rs-fMRI) 数据的分析.
- 研究杏仁体和ACC中的基于种子的连接性.
- 评估灰色物质体积和低频波动的分数幅度,与HC使用时间和孕激素类型相关.
主要成果:
- 较长时间的HC暴露通常与杏仁体和额头区域之间的rs-FC降低,以及ACC和 temporoparietal区域之间的 rs-FC降低有关.
- 这些连接性变化发生的独立于孕激素的雄激素性.
- 孕激素类型确实影响左ACC的灰质体积和特定的ACC-额叶连接.
结论:
- 使用荷尔蒙避孕药的持续时间与大脑功能连接的改变有关,特别是涉及杏仁体和ACC.
- 这些发现表明,长期使用HC可以改变大脑的功能组织.
- 虽然持续时间广泛影响连接性,但孕激素类型可能对区域灰质和局部连接有更具体的影响.
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