在ST段升高心肌梗塞中,血液粘度和血栓负担之间的关系
Mustafa Kaplangoray1, Kenan Toprak2, Yusuf Cekici3
1Department of Cardiology, University of Health Sciences, Mehmet Akif İnan Research and Training Hospital, Sanlíurfa, Turkey.
Clinical hemorheology and microcirculation
|July 31, 2023
概括
增加全血粘度 (WBV) 与ST升高心肌梗塞 (STEMI) 患者的高血栓负担 (TB) 有关. 较高的WBV预测了显著血栓的存在,影响了治疗策略.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 血管生物学 血管生物学
背景情况:
- 增加全血粘度 (WBV) 是ST升高心肌梗塞 (STEMI) 的已知危险因素,与较大的心脏梗塞大小,受损的微循环和较高的死亡率相关.
- 了解影响血栓负担 (TB) 的因素对于管理STEMI结果至关重要.
研究的目的:
- 在STEMI患者中调查WBV和血管学评估结核病之间的关联.
- 为了确定WBV参数是否可以预测患者队列中的高结核病.
主要方法:
- 一项涉及167名接受初级穿皮冠状动脉干预的STEMI患者的横截面研究.
- 使用血红素和总蛋白质水平计算WBV,确定低剪速 (LSR) 和高剪速 (HSR) 值.
- 结核病负担 (TB) 通过心肌梗塞 (TIMI) 中的结核病分类 (Thrombolysis in Myocardial Infarction) 进行分级,将患者分为低 (等级1-3) 和高 (等级4-5) 结核病组.
主要成果:
- 与低结核病患者相比,高结核病患者的平均HSR和LSR值显著高于低结核病患者 (p<0.001两者).
- 接收器操作特征 (ROC) 分析确定了HSR (3.83) 和LSR (21) 的WBV截止值,作为高结核病的显著预测指标,分别具有71%和70%的灵敏度.
- 多变量回归证实HSR (OR=2.408,p=0.020) 和LSR (OR=1.055,p=0.021) 都是高结核病的独立预测因素.
结论:
- 升高的WBV,特别是更高的HSR和LSR值,在STEMI患者中独立地与更大的血栓负担有关.
- 在STEMI中,WBV测量可以作为一个有价值的,非侵入性的生物标志物来评估血栓形成风险.
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