功能性大脑区域与耳病理和任务执行期间的补偿有关:系统性审查
Zaharadeen Jimoh1, Azmi Marouf2, Julianna Zenke3
1Faculty of Science, University of Alberta, Edmonton, Alberta, Canada.
概括
耳会改变大脑活动,特别是在听觉网络. 功能性MRI研究揭示了听觉皮质,耳核和乳腺体的变化,表明了潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 听觉神经科学 听觉神经科学
- 医疗成像医学成像
背景情况:
- 耳是一种复杂的听力障碍,影响全球数百万人.
- 了解 tinnitus 的神经相关性对于开发有效的治疗方法至关重要.
- 功能磁共振成像 (fMRI) 提供了与耳相关的大脑活动模式的见解.
研究的目的:
- 系统地审查和综合fMRI关于 tinnitus 患者大脑区域活动的发现.
- 确定特定的大脑网络和区域,涉及耳病理和补偿.
- 基于改变的大脑活动来探索潜在的治疗点.
主要方法:
- 在多个数据库 (MEDLINE,EMBASE,CINAHL,Web of Science等) 中进行全面的文献搜索. 在2022年4月之前.
- 包括使用fMRI对有耳的成年人类受试者的研究,采用听觉刺激范式.
- 排除非英语研究,动物研究,静止状态fMRI和其他成像方式.
主要成果:
- 听觉皮层 (Heschl's gyrus) 的活动变化,一些研究显示活动增加,而另一些则显示抑制.
- 听力皮层和下 (IC) 之间的连接性下降,在控制混因子后,耳对IC激活没有显著的影响.
- 一般在耳核 (CN) 中激活增加,并显著抑制质门,表明质作为潜在的治疗点.
结论:
- 与对照人群相比,声患者在听觉网络内显著改变了神经元发射模式.
- 耳和声的频繁共存使得分化它们各自的神经效应变得复杂.
- fMRI发现突显了耳中广泛存在的神经变化,并指出马体作为治疗干预的有前途区域.
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