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富血小板血对COVID-19相关的嗅觉功能障碍的有效性:一项受控研究

Jerome R Lechien^1,2,3,4, Sven Saussez^2,4, Luigi A Vaira⁵

¹Department of Otolaryngology, Polyclinic of Poitiers, Elsan, Poitiers, France.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

|July 31, 2023

概括

富血小板血 (PRP) 注射改善了COVID-19患者的嗅觉功能,这些患者有持续的嗅觉功能障碍. 与对照组相比,接受PRP的患者在10周后表现出更好的主观和客观嗅觉结果.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
再生医学是一种再生医学.
传染性疾病传染性疾病

背景情况:

持续的嗅觉功能障碍 (OD) 是2019年冠状病毒疾病 (COVID-19) 的常见后果.
目前用于COVID-19后OD的治疗方法的疗效有限.
富血小板血 (PRP) 具有再生性质,可以帮助嗅觉上皮的修复.

研究的目的:

评估富血小板血 (PRP) 注射在COVID-19患者的嗅觉裂中的有效性,这些患者经历了持续的嗅觉功能障碍 (OD).

主要方法:

一项受控的多中心研究,涉及81名接受PRP注射的患者和78名对照患者.
嗅觉功能在基线和注射后10周被评估,使用嗅觉障碍问卷 (ODQ) 和值,歧视和识别 (TDI) 测试.
来自PRP组的数据与未接受治疗的对照组进行了比较.

主要成果:

接受PRP注射的80.3%的患者在3.4周内报告了嗅觉的主观改善.
与10周的对照组相比,在PRP组中观察到ODQ得分和TDI测试结果的显著改善.
服用PRP组的患者表现出显著降低了帕洛斯米亚的发生率,并改善了生活质量.

结论:

将PRP注入嗅觉裂似乎是COVID-19后持续的嗅觉功能障碍的有效治疗方法.
与未经治疗的对照组相比,接受PRP治疗的患者在嗅觉方面表现出优异的主观和客观改善.
需要进一步的随机对照试验来证实PRP在COVID-19后的OD中比安慰剂优越.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.厌食症是一种厌食症.缺血症缺血症是一种缺血症.嗅觉嗅觉是一种嗅觉.耳鼻喉科耳鼻喉科耳鼻喉科富有血小板血的血.收回回收回收的恢复鼻科鼻科是指鼻科的专家.味道味道味道味道味道

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