身体质量指数,睡眠呼吸障碍,大脑结构和健康儿童的行为之间的关联
Jianqi Cui1,2, Guanya Li1,2, Minmin Zhang1,2
1Center for Brain Imaging, School of Life Science and Technology, Xidian University & Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi'an, Shaanxi 710126, China.
Cerebral cortex (New York, N.Y. : 1991)
|July 31, 2023
概括
预防儿童肥胖可能会减少睡眠呼吸障碍 (SDB),大脑发育异常以及儿童的精神问题. 这项研究将更高的体重指数 (BMI) 与SDB和改变的大脑结构联系在一起,在女孩身上观察到的影响更大.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 精神病学是一个精神病学.
背景情况:
- 儿童超重/肥胖与睡眠呼吸障碍 (SDB),神经,认知和精神问题有关.
- 这些因素与儿童大脑形态学之间的相互作用仍未得到充分研究.
研究的目的:
- 调查身体质量指数 (BMI),SDB,精神病学/认知测量和儿童大脑形态学之间的关联.
- 探索SDB和大脑区域对这些关系的潜在调解效应.
- 检查这些协会中的性别差异.
主要方法:
- 利用青少年大脑认知发育数据集,对8484名9至11岁儿童进行了研究.
- 分析了BMI,SDB,精神病理学,认知功能和大脑形态学 (皮层厚度和体积) 之间的相关性.
- 使用调解分析来了解SDB和特定大脑区域的作用.
主要成果:
- 在BMI和SDB之间发现了积极的关联.
- 无论是BMI还是SDB,都与几个大脑区域的皮质厚度和体积有负相关性.
- SDB部分调解了超重/肥胖对大脑区域的影响.
- 心理病理学和认知功能与BMI和SDB相关.
- SDB和特定的大脑区域调解了BMI对外部化问题和推理的影响.
- 与男孩相比,女孩对肥胖和SDB对大脑,认知和心理健康的影响更大.
结论:
- 预防儿童肥胖对于缓解SDB,神经/认知发育异常和精神问题至关重要.
- SDB在肥胖和不良结果之间的关系中发挥着重要的调解作用.
- 性差异凸显了针对性干预措施的必要性.
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