重新审视对解写试验的系统审查,以更好地告知未来的实践和研究
Anne Spinewine1,2, Emily Reeve3,4, Wade Thompson5,6
1Clinical Pharmacy Research Group, Louvain Drug Research Institute, UCLouvain, Brussels, Belgium.
British journal of clinical pharmacology
|July 31, 2023
概括
抑止处方的研究显示了不一致的试验类别,其中许多包括药物开始. 需要标准化术语和证据综合来更好地描述老年人的研究和实践.
科学领域:
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 老年人过度使用药物是一个重大问题.
- 降低处方的目的是减少不适当的药物使用.
- 对抑郁症的系统性审查增加了.
研究的目的:
- 在最近的描述系统性审查中对试验进行分类.
- 在描述试验分类时识别异质性和不一致性.
- 为未来的抑郁症研究提供建议.
主要方法:
- 对最近的8项抑郁症评价进行了系统审查.
- 122项试验的分类包括试验.
- 将试验分为停止,实施,优化 (包括启动) 和非启动.
主要成果:
- 在审查中确定了试验类别的异质性.
- 32%的试验包括药物开服与抑郁症开服.
- 在如何分类试验方面注意到不一致.
结论:
- 迫切需要在抑郁症的临床试验中标准化术语.
- 需要对证据综合提出建议.
- 改进的研究综合将有助于将研究转化为实践和政策.
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