在没有糖尿病的成年人中,用于体重管理的因克雷丁类似物
Alison Lobkovich1, Pramodini Kale-Pradhan2, Melissa Lipari2
1Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University and Henry Ford Health, Detroit, MI, USA.
The Annals of pharmacotherapy
|July 31, 2023
概括
像提尔泽帕提德,塞马格卢提德和利拉格卢提德这样的因克雷丁类比物显著帮助没有糖尿病的成年人控制体重. 这些药物显示出比安慰剂更高的疗效,而提尔泽帕提德显示出最显著的减肥效果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
- 肥胖医学 肥胖医学
背景情况:
- 包括葡萄糖类1 (GLP-1) 受体激动剂和双葡萄糖依赖型胰岛素型多 (GIP) /GLP-1激动剂在内的因克列类型因其代谢作用而越来越受认可.
- 它们在没有糖尿病的人的体重管理中的作用是一个日益增长的临床兴趣和研究领域.
研究的目的:
- 进行现有随机对照试验的叙述性审查,评估对无糖尿病成年人体重管理中的英克雷丁类 analog 的有效性和安全性.
- 综合关于利拉格卢提德,塞马格卢提德和蒂尔泽帕提德在促进减肥方面的有效性数据.
主要方法:
- 在PubMed/MEDLINE,Scopus和Embase数据库中进行了全面的文献搜索,截至2023年6月.
- 包括的研究是随机对照试验,重点关注没有糖尿病的成年人,接受GLP-1受体激活剂或GIP/GLP-1激活剂治疗以控制体重,体重减轻是主要结果.
主要成果:
- 审查了15项涉及利拉格卢提德,塞马格卢提德和蒂尔泽帕提德的研究,表明与安慰剂或行为疗法相比,有希望的体重管理疗效.
- 观察到的百分比体重减轻范围为5.7%~11.8%的利拉格卢提德,14.9%~17.4%的塞马格卢提德,和15%~20.9%的提尔泽帕提德.
- 在包括的试验中,胃肠道不良反应是最常见的安全问题.
结论:
- 胰岛素类似物是有效的药物疗法,用于在没有糖尿病的成年人中控制体重,表现优于安慰剂.
- 提尔泽帕提德显示出显著的潜力,未来的指导方针可能会进一步定义其作用.
- 临床决策应纳入患者特异性因素,如成本,并发症和同时进行生活方式修改的必要性.
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