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关于中性粒细胞成分及其与免疫细胞在牛皮发育中的相互作用的研究进展

Zhenhui Wang¹, Dongmei Shi²

¹Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

|July 31, 2023

概括

中性粒细胞在牛皮发育中至关重要,分泌关键的炎症分子并与角质细胞相互作用. 了解这些相互作用为新的牛皮治疗提供了基础.

科学领域:

免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

牛皮是一种慢性炎症性疾病.
传统上,IL-23/IL-17轴和Th17细胞被认为是中心的.
新出现的证据强调了中性粒细胞的重要作用.

研究的目的:

要总结中性粒细胞在牛皮病原发生的作用.
探索中性粒细胞与其他免疫细胞和角质细胞的相互作用.
为针对性牛皮治疗提供基础.

主要方法:

牛皮和中性粒细胞的文献综述.
在PubMed和CNKI数据库进行的搜索.
综合发现以得出结论.

主要成果:

中性粒细胞通过分泌IL-23,IL-17和化疗性细胞因子促进牛皮.
激活的角质细胞吸引和激活中性粒细胞,诱导中性粒细胞外细胞陷 (NETs).
中性粒细胞颗粒蛋白激活IL-36,可能会将常见银病转化为一般性性银病 (GPP).

结论:

中性粒细胞成分及其相互作用在牛皮病原发生过程中至关重要.
针对中性粒细胞的向治疗可能是有益的.
为了临床应用,对中性粒细胞功能进行进一步的研究是有必要的.

关键词:

颗粒蛋白质蛋白质的颗粒.作为一个中性恋者.中性粒细胞外细胞陷牛皮是一种牛皮.

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