通过AJ3益生菌调节细胞毒性免疫效应因子功能 益生菌在肌缩侧面硬化症 (ALS) 中
Po-Chun Chen1, Kawaljit Kaur1, Meng-Wei Ko1
1Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave, 90095 Los Angeles, CA, USA.
Critical reviews in immunology
|July 31, 2023
概括
肌缩侧面硬化症 (ALS) 患者表现出高的干扰素- (IFN-γ) 水平. 益生菌菌株Al-Pro (AJ3) 可能会降低这种免疫过活和IL-10水平,可能治疗ALS.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 肌缩侧面硬化症 (ALS) 与来自自然杀手 (NK) 和CD8+T细胞的干扰素 (IFN-γ) 的升高有关.
- 这种免疫失调可能会导致ALS患者中枢神经系统和外周器官的病理.
研究的目的:
- 评估三个益生菌配方的疾病特异性功能:AL-Pro (AJ3) 用于像ALS这样的自身免疫疾病,CA/I-Pro (AJ4) 用于癌症/病毒疾病,NK-CLK (AJ2) 用于免疫平衡.
- 为了比较这些益生菌的免疫激活特征与标准治疗方法,如IL-2和抗体组合.
主要方法:
- 评估了由益生菌配方 (AJ3,AJ4,AJ2) 诱导的外周血液单核细胞 (PBMC),NK细胞和CD8+T细胞的独特激活特征.
- 比较益生菌诱导的免疫细胞激活与单独通过IL-2或与抗CD16或抗CD3/CD28单克隆抗体结合的激活.
- 在不同的治疗条件下测量了IFN-γ与IL-10分泌的比率和IFN-γ诱导水平.
主要成果:
- 益生菌配方表现出独特的免疫激活配置文件,与基于IL-2的治疗不同.
- IL-2 + 抗CD16 mAb显示IFN-γ/IL-10比率最高,其次是IL-2 + sAJ4,IL-2 + sAJ2和IL-2 + sAJ3.
- sAJ3表现出最低的IFN-γ诱导,表明对免疫过度激活的调节作用,特别有利于像ALS这样的自身免疫性疾病.
结论:
- 益生菌菌株AJ3 (Al-Pro) 通过降低IFN-γ的调节和缓解自身免疫反应,显示出作为ALS辅助疗法的潜力.
- AJ3,AJ4和AJ2的独特免疫调节能力突显了它们的特定治疗应用.
- AJ3降低IFN-γ/IL-10比率并减少IFN-γ分泌的能力为管理ALS相关的免疫病理提供了有希望的策略.
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