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在自闭症和注意力缺陷/多动障碍中功能连接的变化通过多声元模式分析揭示了多声元模式分析

Smitha Karavallil Achuthan¹, Despina Stavrinos², Haley B Holm³

¹Department of Psychology & The Center for Innovative Research in Autism, University of Alabama, Tuscaloosa, Alabama, USA.

Brain connectivity

|July 31, 2023

概括

自闭症和ADHD有着不同的大脑连接模式,特别涉及小脑. 这项研究使用功能性MRI揭示了自闭症和ADHD成年人与神经类型相比,这些独特的神经网络差异.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
放射学放射学是一门学科.

背景情况:

自闭症和ADHD是神经发育障碍,具有重叠和独特的神经生物学基础.
破坏大脑连接是自闭症和ADHD的关键特征,但模式是异质的.
了解这些连接差异对于对这些条件的机械洞察至关重要.

研究的目的:

研究自闭症和ADHD成年人的共享和独特的静止状态功能连接 (rsFC) 模式.
使用多声元模式分析 (MVPA) 来基于数据的探索大脑连接,没有先前的假设.
在自闭症和ADHD中,描述小脑与皮质区域的功能连接概况.

主要方法:

在休息状态功能性MRI (rs-fMRI) 数据上使用全脑,连接体全方位的多声素模式分析 (MVPA).
分析了15名自闭症,19名多动症和15名神经类型 (NT) 年轻成年人的数据.
通过使用已识别的显著集群作为感兴趣的种子区域 (ROI) 进行了后期种子-到-voxel分析.

主要成果:

MVPA确定了不同的rsFC模式:大脑小虫9,前和右小脑VI在自闭症和NT成年人中.
右下额头和vermis 9对于ADHD与NT成年人来说是显著的.
右背侧前额皮质区分了自闭症与ADHD成年人;小脑和前额区域显示了特定群体的连接差异.

结论:

该研究强调了自闭症和ADHD成年人与神经类型相比,小脑和皮质连接的具体差异.
这些发现强调小脑在自闭症和ADHD的神经生物学中的作用.
强调研究神经发育障碍中小脑功能连接的重要性.

关键词:

注意力缺陷/多动症障碍.自闭症自闭症是什么功能连接性的功能连接性多声素模式分析分析休息状态 fMRI 的状态.从种子到母细胞的分析.

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