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在乳头甲状腺癌中增加SOCS1和SOCS3的表达及其与预后的关联
1Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. eronatomer@gmail.com.
European review for medical and pharmacological sciences
|July 31, 2023
概括
在乳头甲状腺癌 (PTC) 中抑制细胞因子信号传递 (SOCS) 1和3蛋白的表达增加可能表明预后较差. 这些生物标志物可能有助于PTC诊断和风险分层.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 病理学 病理学 病理学
背景情况:
- 乳头甲状腺癌 (PTC) 通常有良好的预后,但确定不良预后预测因素至关重要.
- 慢性甲状腺炎涉及益炎性细胞因子,可以促进瘤的攻击性特征.
- 细胞因子信号传递抑制剂 (SOCS) 蛋白1和3是细胞因子信号传递的负反抑制剂.
研究的目的:
- 调查SOCS1和SOCS3在PTC和良性甲状腺结节 (BTN) 中的表达.
- 分析SOCS1和SOCS3表达和PTC中的临床病理因素之间的关系.
主要方法:
- 追溯分析了100个PTC和40个BTN案件.
- 对SOCS1和SOCS3.3进行免疫组织化学染色.
- 在PTC和BTN组之间比较蛋白质表达.
- 对病理因素和临床变量相对表达的分析.
主要成果:
- 与BTN相比,PTC中的SOCS1和SOCS3蛋白质表达水平明显高于PTC.
- SOCS1表达与患者年龄相关.
- SOCS3表达与美国甲状腺协会 (ATA) 的风险分层,淋巴结参与,囊入侵和甲状腺外延伸有关.
结论:
- 在PTC中SOCS1和SOCS3的高表达表明它们参与甲状腺癌发生.
- 针对SOCS1和SOCS3的抗体可能有助于PTC的免疫组织学诊断.
- SOCS3表达是PTC中淋巴结状况和风险分层的一个有价值的指标.
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