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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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从含有埃法维伦兹的疗法转换后肌肉内卡博特格拉维尔和里尔皮维林度

Sara Bettonte1,2, Mattia Berton1,2, Felix Stader3

  • 1Division of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.

British journal of clinical pharmacology
|July 31, 2023
PubMed
概括

在 efavirenz 后切换到注射式卡博特格拉维尔/里尔皮维林 (IM CAB/RPV) 是安全的. 基于生理学的药物动力学建模表明药物水平仍然有效,在过渡期间避免低于最佳度.

关键词:
PBPK 建模,药理动力学药物相互作用 药物相互作用埃法维伦兹 (efavirenz) 是一种长效卡博特格拉维尔 (cabotegravir) 是一种长效的药物.长效的里尔皮维林 (rilpivirine) 是一种

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