基于挤出的系统用于局部和透皮药物输送
Ana Luiza Lima1, Idejan P Gross1, Lívia Lira de Sá-Barreto1
1Laboratory of Food, Drugs, and Cosmetics (LTMAC), School of Health Sciences, University of Brasilia, Brasília, DF, Brazil.
Expert opinion on drug delivery
|July 31, 2023
概括
基于挤出的技术,如热挤出 (HME) 和沉积建模 (FDM) 3D打印,通过增强通过皮肤屏障的药物扩散,为局部和透皮药物输送提供了创新的解决方案. 尽管存在一些局限性,但这些方法可以使设备与患者匹配,并提高生物可用性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
背景情况:
- 通过皮肤输送药物提供了一种安全的,非侵入性的途径,用于全身或局部治疗效果.
- 开发有效的局部配方,克服皮肤的天然障碍,仍然是制药科学的重大挑战.
研究的目的:
- 为开发先进的局部和透皮药物递送系统提供基于挤出技术的全面概述.
- 通过挤出方法促进增强药物透的背后的理论原则.
- 为了对比当前基于挤出的制药工艺与既定的制造技术.
主要方法:
- 基于挤出技术的审查,重点是热挤出 (HME) 和化沉积模型 (FDM) 3D打印.
- 对药物扩散和皮肤透增强的理论模型的分析.
- 对HME和FDM3D打印与传统制药制造的比较评估.
主要成果:
- 挤出技术使独特的药物辅助剂相互作用成为可能,优化了通过皮肤屏障的药物扩散.
- 热挤出 (HME) 和FDM3D打印允许创建新型剂型,包括具有精确解剖适配的剂型.
- 这些方法在通过皮肤治疗的工业可扩展性和生物可用性增强方面具有优势.
结论:
- 基于挤出的技术,特别是HME和FDM3D打印,在局部和透皮药物输送方面取得了重大进展.
- 虽然存在热稳定性和辅助剂选择等挑战,但工业适应性和患者匹配设备的好处需要进一步投资.
- 这些创新技术有望改善治疗结果和患者在药物输送中的遵守.
相关概念视频
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
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