用大场 CZT 马相机对 Tc-pertechnetate 甲状腺摄取量的定量分析:SPECT/CT 和平面采集之间的可行性和比较
Benjamin Serrano1, Régis Amblard2, Tiffany Beaumont3
1Medical Physics Department, Centre Hospitalier Princesse Grace, Monaco, Monaco. bserrano@chpg.mc.
EJNMMI physics
|July 31, 2023
概括
这项研究表明, Telluride (CZT) 摄像机使用SPECT/CT成像准确估计甲状腺吸收量 (TU),与平面扫描相似. 然而,CT扫描增加了对甲状腺的辐射暴露.
科学领域:
- 核医学是一种核医学.
- 医学成像技术 医学成像技术
- 辐射物理学 辐射物理学
背景情况:
- Telluride (CZT) 摄像机技术的进步为改善核医学成像提供了潜力.
- 准确量化甲状腺吸收 (TU) 对于诊断和管理甲状腺疾病至关重要.
- 评估新的成像系统需要与既有方法进行比较,并评估辐射剂量计.
研究的目的:
- 与平面成像相比,评估使用单光子发射计算断层扫描 (SPECT) 和无衰减校正 (AC) 的大型视野CZT摄像机估计甲状腺吸收 (TU) 的准确性.
- 为了确定与追踪剂和额外的计算机断层扫描 (CT) 扫描相关的辐射剂量.
主要方法:
- 通过使用甲状腺幻体,为平面,SPECT/CT与AC (Tomo-AC) 和SPECT/CT没有AC (Tomo-NoAC) 建立了交叉校准因子.
- 在人形幻体上进行了平面和SPECT/CT采集,23名患者接受了[99mTc]-pertechnetate.
- 估计了绝对甲状腺活性 (AThA) 和TU,并使用ICRP报告和VirtualDoseTMCT软件计算了辐射剂量.
主要成果:
- 交叉校准因子在成像技术之间有很大的差异.
- 估计的AThA与所有方法的理论值有很高的相关性,Tomo-AC显示出最低的百分比差异 (-1.3±5.2%).
- 甲状腺吸收 (TU) 估计在平面和SPECT/CT方法 (r > 0.93) 之间高度相关,有效剂量为0.34 mSv (CT) + 0.95 mSv (NM),甲状腺吸收剂量为3.88 mGy (CT) + 1.74 mGy (NM).
结论:
- 绝对甲状腺活动估计是可行的新一代CZT摄像机使用平面和SPECT/CT收购.
- 在SPECT/CT成像中,TU的精度与传统平面成像相美.
- 在SPECT/CT成像中使用CT导致甲状腺额外的辐射暴露.
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