载有提摩农的自我纳米乳化药物输送系统,用于预防缺血/再输液损伤
Badr Bahloul1, Roua Chaabani2, Yosri Zahra2
1Drug Development Laboratory (LR12ES09), Faculty of Pharmacy, University of Monastir, 1 Rue Avicenne 5000, Monastir, Tunisia. badrpharm07@gmail.com.
Drug delivery and translational research
|July 31, 2023
概括
这项研究开发了一种自纳米乳化药物递送系统 (SNEDDS) 用于提摩 (TQ). 装有TQ的SNEDDS通过减少氧化应激和炎症,有效地保护大鼠肝脏免受缺血/再损伤.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
- 细胞生物学 细胞生物学
背景情况:
- 肝脏缺血/再输 (I/R) 损伤是一个重大的临床挑战.
- 蒂莫金 (TQ) 显示出潜在的治疗益处,但需要有效的输送.
- 开发先进的药物输送系统对于提高TQ的疗效至关重要.
研究的目的:
- 开发和表征一个自纳米乳化药物递送系统 (SNEDDS) 用于蒂莫基 (TQ).
- 评估TQ加载SNEDDS在小鼠模型中对肝脏缺血/再输 (I/R) 损伤的保护作用.
- 评估潜在的机制,包括氧化应激,炎症和亡.
主要方法:
- SNEDDS的制药特征 (滴滴大小,泽塔潜力,稳定性,溶解).
- 在体内研究涉及口服预处理大鼠的TQ载SNEDDS.
- 生物化学测定,组织学分析 (血素-乙),免疫光和RT-PCR来评估损伤标记物,氧化应激,炎症和亡.
主要成果:
- 开发的TQ装载SNEDDS在体外表现出有利的特征,具有高药物释放率.
- 用TQ加载的SNEDDS进行预治疗显著减少肝酶释放 (ALT,AST) 和保存肝脏组织学.
- 该配方表现出强大的抗氧化作用 (增加SOD,减少MDA),抗炎作用 (降低CRP,MPO,炎症基因表达),并促进细胞存活 (增强Bcl-2/Bax比率).
结论:
- 在SNEDDS中封装的TQ提供了对大鼠肝脏I/R损伤的显著保护.
- SNEDDS提高了TQ的生物可用性和治疗疗效,以保护肝脏.
- 保护机制包括减轻氧化应激,炎症和亡.
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