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一个统计框架来识别细胞类型,其基因调节比例与复杂疾病有关

Wei Liu1, Wenxuan Deng2, Ming Chen2

  • 1Program of Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut, United States of America.

PLoS genetics
|July 31, 2023
PubMed
概括

这项研究引入了细胞类型广泛关联研究 (cWAS),这是一种将遗传数据和细胞比例与疾病风险联系起来的新方法. cWAS识别了与复杂疾病相关的特定细胞类型,有助于发现生物标志物.

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相关概念视频

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...