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新生儿抗生素耐药性模式被指向北印度的儿科紧急情况:一项前性队列研究

Jogender Kumar¹, Prakash Kumar Soni¹, Archana Angrup²

¹From the Department of Pediatrics.

The Pediatric infectious disease journal

|July 31, 2023

概括

新生儿败血症是全球主要的健康问题,特别是在发展中国家. 这项研究揭示了超出预期的新生儿中血症和令人担忧的抗菌素耐药性 (AMR) 的高负担,需要紧急干预.

科学领域:

新生儿医学新生儿医学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

败血症是全球新生儿死亡的主要原因,低收入和中等收入国家的发病率更高.
在发展中国家的新生儿中,关于病原体概况和抗菌素耐药性 (AMR) 的数据有限.
这项研究通过检查新生儿转移到第三级护理中心的败血症来解决知识差距.

研究的目的:

为了确定出生的新生儿中败血症的病原体谱.
评估这些病原体中的抗菌素耐药性 (AMR) 模式.
在资源有限的环境中为新生儿败血症管理提供公共卫生策略的信息.

主要方法:

一项前性队列研究招募了1072名怀疑患有败血症的新生儿.
血液或脑脊液培养物用于病原体识别和抗菌素敏感性测试.
使用标准标准定义了多药性耐药性,并跟踪新生儿直到出院或死亡.

主要成果:

格拉姆阴性细菌是导致败血症的最常见原因 (10%),其次是格拉姆阳性细菌和真菌.
关键的病原体包括凝聚酶阴性葡萄球菌,Candida spp.,Klebsiella spp.和Acinetobacter spp.
观察到多重耐药性 (68.6%) 的高患病率,特别是在Klebsiella spp. (62%),Acinetobacter spp. 的使用情况. (83%) 和凝固酶阴性葡萄球菌 (82%).
整体住院死亡率为11.6%.

结论:

新生儿败血症的严重负担和抗菌素耐药性 (AMR) 的高率需要立即关注.
加强败血症预防策略的协调实施至关重要.
加强所有卫生保健层面的抗微生物药物管理对于打击不断上升的抗菌素耐药性至关重要.

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