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Updated: Jul 20, 2025

Author Spotlight: Exploring the Role of Unfolded Protein Response in HIV-1 Replication and Infectivity
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不同的蛋白质组反应性影响了通过药理学内质网膜蛋白质稳定调节器对展开的蛋白质反应的选择性激活

Gabriel M Kline1, Ryan J Paxman1, Chung-Yon Lin1

  • 1Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, United States.

ACS chemical biology
|July 31, 2023
PubMed
概括

激活转录因子6 (ATF6) 有助于蛋白质稳定. 化合物AA132通过修改内网膜 (ER) 蛋白质二硫化异相酶 (PDIs) 全球激活未折叠蛋白质反应 (UPR),与选择性ATF6激活剂AA147.2不同.

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