相关实验视频

Updated: Jul 20, 2025

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

在C型肝炎根除后,重新接种B型肝炎疫苗给以前没有反应的患者

Jesse G Powell¹, Spencer R Goble², Jose D Debes^1,3

¹Department of Gastroenterology and Hepatology, Hennepin Healthcare, Minneapolis, Minnesota, USA.

The Journal of infectious diseases

|July 31, 2023

概括

慢性型肝炎病毒 (HCV) 患者没有对乙型肝炎病毒 (HBV) 疫苗产生反应,在HCV治疗后再接种疫苗后,其抗体水平有所改善. 这表明再接种疫苗对这个患者群体有好处.

科学领域:

肝病学肝病学是一种肝病学.
免疫学免疫学免疫学
疫苗学疫苗学疫苗学

背景情况:

患有慢性型肝炎病毒 (HCV) 感染的患者对乙型肝炎病毒 (HBV) 接种疫苗的免疫反应减弱.
这种受损的反应需要探索替代疫苗接种策略,以便在HCV患者中有效预防HBV.

研究的目的:

为了评估之前没有反应的患者在成功治疗HCV后,用HBV疫苗重新接种疫苗的疗效.
要确定在HCV中实现持续病毒学反应 (SVR) 是否可以恢复对HBV疫苗接种的反应.

主要方法:

一项前性研究招募了先前没有对HBV疫苗产生反应的患者和有HCV病史的患者.
患者在实现HCV根除后接受HBV再接种疫苗.
测量乙型肝炎表面抗体 (HBsAb) 水平是在疫苗接种系列完成后的一个月.

主要成果:

在34名注册患者中,31人完成了随访HBsAb测试.
显著的比例,21名患者 (67.7%),在再接种疫苗后显示出反应性HBsAb水平.
在HBsAb反应性和患者人口统计 (年龄,性别,种族) 或晚期纤维化之间没有发现显著的关联.

结论:

在成功治疗HCV后,重新接种HBV疫苗可以在以前没有反应的人中引起保护性免疫反应.
这些发现支持考虑对已经清除HCV感染的患者进行HBV再接种疫苗.
在HCV患者中优化HBV疫苗策略对于预防HBV/HCV共感染及其并发症至关重要.

关键词:

直接作用的抗病毒药物.乙型肝炎病毒疫苗乙型肝炎病毒疫苗没有反应.在C型肝炎病毒的感染中,

更多相关视频

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

相关概念视频

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...

Vaccinations

Vaccinations

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...

Cross-reactivity

Cross-reactivity