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在塞拉利昂中风. 艾滋病毒感染者的中风风险因素:一项前性病例控制研究

Mamadu Baldeh¹, Daniel Youkee², Sulaiman Lakoh³

¹College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone; Medical Research Council Gambia at London School of Hygiene and Tropical Medicine, UK.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

|July 31, 2023

概括

与没有艾滋病毒的人相比,患有人类免疫缺陷病毒 (HIV) 的中风患者更年轻,患高血压率更低. 建议对中风和艾滋病毒进行综合治疗.

科学领域:

神经学神经学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

脑卒中是一个重大的健康问题,但它与西非人体免疫缺陷病毒 (HIV) 的关联仍未得到充分研究.
了解艾滋病毒阳性个体中风的特征对于有针对性的干预至关重要.

研究的目的:

为了比较塞拉利昂的艾滋病毒阳性和艾滋病毒阴性中风患者之间的中风类型,临床表现,风险因素和结果.
研究艾滋病毒对中风病因和预后在低患病率环境中的贡献.

主要方法:

在塞拉利昂弗里敦的两家三级医院进行了一项病例控制研究,涉及511名中风患者.
艾滋病毒阳性中风患者 (病例) 与艾滋病毒阴性中风患者 (对照组) 相比,年龄和性别相匹配,比例为1:4.
统计分析包括皮尔森奇平方,Pired-T和曼-惠特尼U测试,以比较分类和连续变量.

主要成果:

在511名患者中,36人 (7.1%) 呈艾滋病毒阳性. 艾滋病毒阳性患者明显年轻 (平均年龄为49岁与58岁,p<0.001).
在两组中,缺血性中风是主要的类型 (艾滋病毒阳性:69.4%,艾滋病毒阴性:53.5%). 在HIV阳性患者中,高血压的发生率较低 (63.9%与86.1%,p=0.001).
较低的CD4+计数与增加的住院死亡率有关 (p<0.001).

结论:

艾滋病毒阳性个体中风的表现不同,发病年龄较小,高血压率较低.
调查结果强调了对艾滋病毒和中风护理的综合管理策略的需要.
需要进一步的研究来阐明该地区艾滋病毒和中风之间的复杂关系.

关键词:

巴瑟尔指数是巴瑟尔指数.艾滋病病毒艾滋病病毒艾滋病病毒美国国家卫生保健局 (NIHSSSS)结果结果的结果.塞拉利昂塞拉利昂一次性中风,中风.在撒哈拉以南的非洲.

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