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鼠 L4/L5 面状囊带的表征 拉伸失效负荷对拉伸失效负荷的宏观机械和微观结构反应
Sagar Singh1, Beth A Winkelstein2
1Department of Bioengineering, University of Pennsylvania, 210 S 33rd St., Philadelphia, PA 19104, United States.
Journal of biomechanics
|July 31, 2023
概括
这项研究表明,随着大鼠腰部面膜囊拉伸,原纤维变得更加无组织. 负载过程中这种增加的混乱可能会激活感官神经,导致腰部疼痛.
科学领域:
- 生物机械工程 生物机械工程
- 人体解剖学 解剖学 解剖学
- 疼痛研究 疼痛研究
背景情况:
- 腰部疼痛是一个广泛的全球健康问题.
- 腰侧囊带,由感觉神经元内化,是一个重要的疼痛来源.
- 对于腰部面膜囊的多尺度机械行为,人们的理解有限.
研究的目的:
- 在拉伸失效期间,对大鼠腰部面膜囊的宏观和纤维尺度变化进行特征化.
- 研究原纤维组织与机械负荷之间的关系.
主要方法:
- 拉伸测试7个大鼠腰部面膜囊在0.08毫米/秒的拉伸测试.
- 集成的偏光成像,以捕捉当地的光纤对齐.
- 在加载到故障期间测量力,位移,应变和循环变异.
主要成果:
- 力量,位移和最大的主力应变随着张力增加而增加.
- 原纤维的循环变异增加,表明更大的混乱.
- 异常的原纤维调整事件随着负载显著增加.
结论:
- 在加载过程中,观察到侧面囊中的原蛋白失调和重新调整的增加.
- 这些变化提供了关于带附带神经激活机制的见解.
- 这可能会阐明机械负荷导致腰部疼痛的途径.
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01:20Normal Strain under Axial Loading
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Normal strain under axial loading is an important concept in the field of mechanics of materials. Axial loading implies the application of a force along the axis of a material, like a column or bar. This force can either compress or stretch the material. In the context of axial loading, normal strain is the deformation experienced by the material in the direction of the loading force. It's calculated as the change in length divided by the original length of the material. This unitless ratio...
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01:15Relation between Poisson's ratio, Modulus of Elasticity and Modulus of Rigidity
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Deformation occurs in axial and transverse directions when an axial load is applied to a slender bar. This deformation impacts the cubic element within the bar, transforming it into either a rectangular parallelepiped or a rhombus, contingent on its orientation. This transformation process induces shearing strain. Axial loading elicits both shearing and normal strains. Applying an axial load instigates equal normal and shearing stresses on elements oriented at a 45° angle to the load axis.
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