Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

1.4K
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
1.4K
Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

3.7K
Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
3.7K
Ankle Joint01:10

Ankle Joint

1.6K
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
1.6K
Knee Joint01:23

Knee Joint

1.9K
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris...
1.9K
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

2.3K
As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
2.3K
Glycosaminoglycans01:23

Glycosaminoglycans

4.9K
Glycosaminoglycans (GAGs), also known as mucopolysaccharides, are long and linear polymers comprising of specific repeating disaccharides - the amino sugar that can be N-acetylglucosamine or N-acetylgalactosamine, and a uronic acid that is usually glucuronic acid or iduronic acid.
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
4.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Is a Resorbable Citrate-based Bioceramic Device Associated With Osseous Integration? An Early Retrospective MRI Analysis.

Clinical orthopaedics and related research·2026
Same author

Outcomes Following Conversion of Ankle Fusion to Transfibular Total Ankle Arthroplasty.

Foot & ankle orthopaedics·2026
Same author

A qualitative study to inform a parental education intervention for unintentional child injury prevention in rural Nepal.

Frontiers in public health·2026
Same author

Immortalization and Targeted Enrichment of HIV-Infected CD4<sup>+</sup> T-Cells from Patients Under Antiretroviral Therapy.

International journal of molecular sciences·2026
Same author

Outcomes of iliac crest bone marrow aspirate injection in the treatment of recalcitrant plantar fasciitis.

International orthopaedics·2026
Same author

Synovial histopathology in common orthopaedic joint conditions assessed with a modified Krenn synovitis score.

Histology and histopathology·2025

相关实验视频

Updated: Jul 20, 2025

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
09:58

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

20.8K

轻微的膜炎会损害合体环境中的原体.

Sharada Paudel1, Tyler Feltham2, Lumanti Manandhar3

  • 1Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.

Cells, tissues, organs
|July 31, 2023
PubMed
概括

轻度膜炎通过抑制状细胞基质生产,对软骨修复产生负面影响. 这一发现凸显了治疗突炎对于有效的关节愈合的重要性.

关键词:
冠状细胞是什么意思 冠状细胞是什么意思混凝土生成 (chondrogenesis) 是一种纤维细胞类同胞细胞类似于纤维细胞.综合性炎症 综合性炎症这就是Synovium.

更多相关视频

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

3.8K
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.2K

相关实验视频

Last Updated: Jul 20, 2025

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
09:58

A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid

Published on: January 31, 2012

20.8K
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

3.8K
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

12.2K

科学领域:

  • 整形外科 整形外科 整形外科
  • 类风湿病学 类风湿病学
  • 细胞生物学 细胞生物学

背景情况:

  • 轻度突炎在软骨修复中的作用经常被忽视.
  • 突炎,突膜的炎症,可以影响关节的愈合环境.
  • 纤维细胞样同胞细胞 (FLS) 在关节稳态和炎症中起着至关重要的作用.

研究的目的:

  • 为了研究轻度突炎对体生成的影响.
  • 为了确定纤维细胞样同胞细胞 (FLSs) 从同胞细胞关节对状细胞功能的影响.
  • 评估突炎严重程度与冠状细胞矩阵生产之间的关系.

主要方法:

  • 对21个突样本 (13个正常,8个轻微突炎) 的组织学分析.
  • 纤维细胞样同胞细胞 (FLS) 的隔离和培养.
  • 从FLSs获得条件介质的冠状细胞培养和糖氨酸甘氨酸生产的评估.

主要成果:

  • 轻度突炎的特征是CD3+淋巴细胞在底线层的增加.
  • 从FLSs中用条件介质治疗的冠状细胞显示了减少的葡萄糖氨基酸甘氨酸产量.
  • 葡萄糖氨基甘油的产量与突炎得分有负相关性.

结论:

  • 轻微的突炎通过FLSs抑制状细胞矩阵的产生,从而损害了状细胞的生成.
  • 即使是轻微的突关节炎也会显著改变关节环境,损害软骨修复的结果.
  • 向突炎可能对改善软骨修复策略至关重要.