青春期肥胖和执行功能之间的相互联系:肠道微生物群的作用
Jamil M Lane1, Robert O Wright2, Shoshannah Eggers3
1Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neuroscience and biobehavioral reviews
|July 31, 2023
概括
青少年肥胖与执行功能缺陷有关. 肠道微生物组可能在这种关系中发挥关键作用,可能会调解由肥胖影响的大脑路径.
科学领域:
- 神经科学是一个神经科学.
- 微生物组研究 微生物组研究
- 青少年健康 青少年健康
背景情况:
- 青少年肥胖是美国的一个重大公共卫生问题.
- 肥胖与执行功能受损有关.
- 人们越来越认识到肠道微生物组在肥胖和大脑健康方面的作用.
研究的目的:
- 审查有关青少年肥胖,执行功能和肠道微生物组的文献.
- 在青少年肥胖的背景下探索肠道-微生物组-大脑轴.
- 确定肠道微生物组在执行功能缺陷中的潜在调解作用.
主要方法:
- 现有研究的叙述性审查.
- 综合研究将青少年肥胖,执行功能和肠道微生物组联系起来.
- 在肥胖病理生理学中分析肠道-微生物组-大脑轴.
主要成果:
- 有证据表明,肥胖,执行功能和肠道微生物组之间存在双向关系.
- 肠道微生物组可能会调解连接肥胖和执行功能障碍的神经生物学途径.
- 确定了受肥胖影响和受微生物群影响的特定执行功能领域.
结论:
- 肠道微生物组是青少年肥胖和执行功能缺陷之间的联系的潜在调解者.
- 了解这一轴为与肥胖相关的认知障碍提供了新的见解.
- 准肠道微生物组可能是青少年肥胖症和相关的执行功能障碍的新疗法策略.
相关概念视频
Anatomy of the Intestines
72.5K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.5K
Obesity
534
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
534
Regulation of Food Intake
281
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
281
Physiology of Enteric Nervous System and Gut Health
312
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
312
Binge Eating Disorders
145
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
145
Regulation of the Digestive System
690
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
The effectors in this regulation system are glands and smooth muscles. Activation of...
690


