纤维肌痛患者的自主小纤维病理学
Pietro Falco1, Eleonora Galosi1, Giulia Di Stefano1
1Department of Human Neuroscience, Sapienza University, Rome, Italy.
纤维肌痛患者的小纤维病理 (SFP) 显示皮肤自主神经纤维减少,表明SFP也会损害这些神经. 然而,这种神经损伤与纤维肌痛中自主性症状严重程度无关.
科学领域:
- 神经学 神经学
- 病理学 病理学 病理学
- 皮肤病学 皮肤病学
背景情况:
- 纤维肌痛综合征 (FMS) 通常与小纤维病理 (SFP) 相关,其特征是皮内神经纤维损失.
- 目前尚不清楚与FMS相关的SFP是否还涉及皮肤自主神经纤维的损伤及其与自主症状的关系.
研究的目的:
- 调查纤维肌痛相关的SFP是否暗示皮肤自主神经纤维损伤.
- 确定这种自主神经损伤与FMS患者自主症状的严重程度之间的关联.
主要方法:
- 一项临床和皮肤活检研究涉及138名参与者:58名FMS患者,48名健康对照和32名小纤维神经病变患者.
- 皮肤活检分析了皮肤内的神经纤维密度,以及 piloerector 肌肉和汗腺 (SGNFD) 中的神经纤维密度.
- 自主症状使用复合自主症状得分31 (31项COMPASS) 问卷进行评估.
主要成果:
- 与健康受试者相比,患有纤维肌痛相关的SFP患者表现出减少的Piloerector肌肉和SGNFD.
- 在FMS患者中,自主小纤维损伤与自主症状的严重程度没有相关性.
- 与小纤维神经病变患者相比,患有SFP的患者表现出更高的内皮层,肌肉发射器和SGNFD.
结论:
- 患有SFP的纤维肌痛患者表现出皮肤自主小纤维的减少,反映出皮肤内神经纤维的损失.
- 这表明纤维肌痛中SFP包括自主小神经纤维损伤.
- 纤维肌痛中这种自主小纤维损伤的临床意义仍然未确定,因为与症状严重程度缺乏相关性.
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