通过使用在民间医学中被称为"三个toronjiles"的混合物来缓解的效果的药理缺点
Guadalupe E Ángeles-López1, Angélica Hernández-Ruíz1, Ma Eva González-Trujano2
1Departamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Journal of ethnopharmacology
|July 31, 2023
概括
墨西哥药用植物Agastache mexicana (PT,WT) 显示起解作用,但添加Dracocephalum moldavica (BT) 会减少或阻止这种活性,这表明植物混合物的潜在缺点.
科学领域:
- 药理学 药理学是指药理学的学科.
- 民族植物学 民族植物学
- 植物化学 植物化学
背景情况:
- 传统的墨西哥医学使用Agastache mexicana亚种. 墨西哥人 (PT),A.墨西哥人亚种. xolocotziana (WT) 和 Dracocephalum moldavica (BT) 作为胃肠的"三种" .
- 这些植物组合的协同作用或对抗作用尚未得到充分理解.
研究的目的:
- 评估PT,WT和BT水性提取物的单独和联合的解活性.
- 为了比较这三种物种的化学特征.
主要方法:
- 通过使用用KCl,EFS或ACH合并的几内亚猪内准备剂来评估解活性.
- PT,WT和BT的水性提取物被单独和组合测试.
- 化学分析涉及薄层和超高压液体色谱.
- 在小鼠中确定了急性毒性.
主要成果:
- PT和WT提取物对KCl,EFS和ACH诱导的收缩产生了剂量依赖的解作用.
- 单独的BT提取物没有表现出解活性.
- PT和WT提取物的组合显示出协同作用的抗效应.
- 将BT提取物添加到PT+WT组合中可以抑制或阻断解活性,这取决于BT度和刺激方法.
- 化学分析显示PT和WT之间存在相似之处,但与BT有明显的差异.
- 对于小鼠的单个提取物,没有观察到急性毒性.
结论:
- PT和WT的水性提取物具有解性质,支持它们用于胃肠道疾病的传统用途.
- 在PT和WT的组合中加入BT显著减少或否定了解活性.
- 这项研究强调,结合药用植物可能会导致对抗作用,降低治疗效果.
关键词:
A.gastache 墨西哥亚种. xolocotzianaanaana 在线观看 在线观看 在线观看墨西哥亚种的Agastache墨西哥亚种. 墨西哥的墨西哥人.龙头头 (Dracocephalum moldavica) 的意思是:龙头头 (Dracocephalum moldavica) 的意思是:龙头头 (Dracocephalum moldavica) 的意思是:龙头头 (Dracocephalum moldavica) 的意思是:龙头头头 (Dracocephalum moldavica) 的意思是:龙头头头 (Dracocephalum moldavica) 的意思是:龙头头头 (Dracocephalum moldavica) 的意思是:龙头头头 (Dracocephalum moldavica) 的意思是:龙头头头 (Dracocephalum moldavica) 的意思是:龙头头 (Dracocephalum moldavica) 的意思是:龙头头 (Dracocephalum moldavica) 的意思是:龙头 (Dracocephalum moldavica) 的意思是:具有解作用的效果.三个龙的
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