细胞外矩阵 - 免疫微环境在癌症治疗中的交叉交谈:挑战和机遇
Lara Closset1, Okan Gultekin2, Sahar Salehi3
1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solnavägen 9, Stockholm 171 65, Sweden; Saint-Antoine Research center (CRSA), UMR_S 938, INSERM, Sorbonne Université, Paris F-75012, France.
概括
癌症免疫疗法和传统治疗受瘤免疫微环境 (TIME) 和细胞外矩阵 (ECM) 的影响. 针对TIME-ECM交叉通话提供了改善癌症治疗结果的新策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物化学 生化学
背景情况:
- 癌症免疫疗法可以改善患者的治疗结果,但根据癌症类型显示异质反应.
- 瘤免疫微环境 (TIME) 显著影响免疫治疗和常规癌症治疗 (化疗,放射治疗,手术) 的疗效.
- 细胞外基质 (ECM) 是免疫细胞功能和耐药性的关键调节者,它被癌症治疗动态改变.
研究的目的:
- 为了审查癌症中TIME和ECM之间的分子交叉声.
- 讨论这种交叉对癌症进展和临床干预的影响.
- 探索ECM和TIME与现有瘤治疗相结合的共同向的未来方向.
主要方法:
- 关于TIME和ECM之间的分子交叉声的文献综述.
- 分析 TIME-ECM 相互作用如何影响癌症进展.
- 讨论涉及ECM和TIME共同向的治疗策略.
主要成果:
- 时间和ECM是紧密联系在一起的,交叉声会影响治疗阻力和反应.
- 癌症疗法调节TIME和ECM,导致复杂的,有时是对立的,对瘤进展的影响.
- 了解TIME-ECM交音对于开发更有效的组合疗法至关重要.
结论:
- 瘤免疫微环境和细胞外基质之间的交叉交互为提高癌症治疗效率提供了显著的机会.
- 结合ECM和TIME调制与手术,化疗或放射治疗的联合向策略有望改善患者的治疗结果.
- 对TIME-ECM相互作用的分子机制的进一步研究对于推进临床干预至关重要.
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