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Updated: Jul 20, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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通过偏向性细胞内激动剂保护的B类GPCR激活

Li-Hua Zhao1,2, Qian He3,4, Qingning Yuan3

  • 1State Key Laboratory of Drug Research, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. zhaolihuawendy@simm.ac.cn.

Nature
|July 31, 2023
PubMed
概括

研究人员发现了针对副甲状腺激素1受体 (PTH1R) 的小分子药物的新结合部位. 这一发现可能导致B类G蛋白结合受体 (GPCR) 的口服药物.

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