在患有多发性硬化症的人群中,认知障碍与残疾之间的关联
Bianka Suchá1, Pavel Šiarnik1, Stanislava Klobucká2
11st Department of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Neuro endocrinology letters
|July 31, 2023
概括
多发性硬化症 (MS) 患者的认知障碍在12个月内显示出有限的下降. 然而,认知测试与残疾指标相关,表明它们在综合性MS评估中的价值.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 康复医学 康复医学 康复医学
背景情况:
- 认知障碍 (CI) 是多发性硬化症 (PwMS) 患者常见的并发症,影响各种疾病阶段和残疾水平.
- 了解CI的进展及其与身体残疾的关系对于全面的患者管理至关重要.
研究的目的:
- 在12个月的时间内调查PwMS的认知衰退.
- 在12个月的PwMS中检查认知功能和身体残疾之间的关联.
主要方法:
- 多发性硬化症简要国际认知评估 (BICAMS) 电池,包括SDMT,CVLT和BVMT-R,评估了认知.
- 身体残疾使用扩展残疾状况尺度 (EDSS),定时25英尺步行 (T25FW) 和9洞测试 (9-HPT) 来衡量.
- 统计分析包括威尔科克森认知变化签名等级测试和斯皮尔曼认知障碍关联的相关性.
主要成果:
- 统计学上显著的差异仅在分类口语学习测试 (CVLT) 中观察到,这表明在12个月内其他测试领域 (SDMT,BVMT-R) 的认知下降有限.
- 符号数字模式测试 (SDMT) 在两个时间点中显示出与残疾指标的显著相关性.
- 在第二次检查中,BICAMS和9-HPT之间以及SDMT,BVMT-R和EDSS之间发现了相关性.
结论:
- 可能需要更长的研究时间来检测PwMS显著的认知衰退.
- 仅仅扩展残疾状态量表 (EDSS) 可能无法完全捕捉患者的临床状态,因为它忽略了认知和上肢功能评估.
- 将认知测试和上肢功能测试 (如9-HPT) 与EDSS相结合,可以更全面地评估PwMS临床状况.
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