睡眠测量和心血管疾病在2型糖尿病中
Caroline J Magri1, Sara Xuereb1, Rachel-Anne Xuereb1
1Mater Dei Hospital, Malta.
Clinical medicine (London, England)
|July 31, 2023
概括
睡眠质量差与2型糖尿病中的大血管疾病有关. 更高的红细胞分布宽度 (RDW) 和良好的睡眠也独立预测T2DM患者的心血管健康.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
背景情况:
- 2型糖尿病 (T2DM) 是一个日益严重的全球健康问题.
- 心血管疾病 (CVD) 是T2DM的主要并发症.
- 在T2DM患者中,睡眠质量与心血管疾病之间的独立关联需要进一步调查.
研究的目的:
- 调查T2DM患者睡眠不足与心血管疾病之间的独立关联.
- 确定与睡眠相关的因素,有助于T2DM心血管并发症.
主要方法:
- 一项涉及108名年龄在40-80岁的T2DM患者的横截面研究.
- 使用动图和匹兹堡睡眠质量指数 (PSQI) 进行睡眠评估.
- 对心血管并发症的分析,包括动脉内膜介质厚度 (CIMT) 和相关风险因素.
主要成果:
- 在动图测量睡眠参数和T2DM相关的血管并发症之间没有发现任何关联.
- 通过PSQI评估的睡眠质量差,在单变量分析中显著与大脑血管疾病有关.
- 多变量分析确定红细胞分布宽度 (RDW) 和良好的睡眠质量是宏血管疾病的独立预测因素. 增加的BMI,RDW和抑郁症得分与亚临床动脉样硬化 (异常CIMT) 有关.
结论:
- 睡眠质量差和RDW水平升高独立地与T2DM患者的大脑血管疾病有关.
- 增加的体重指数 (BMI) 和抑郁症在这个人群中也与亚临床动脉样硬化 (通过CIMT测量) 独立相关.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Carbohydrate Metabolism
11.3K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.3K
Diabetes: Symptoms, Diagnosis, and Complications
593
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
593
Diabetes Mellitus: Overview and Type I Subtype
2.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.8K
Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
119
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
119


