针对呼吸道疾病的宁血管酶系统
Phyllis X L Gan1, W Liao2, Kira M Linke3
1Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore, Singapore.
Advances in pharmacology (San Diego, Calif.)
|July 31, 2023
概括
向宁-血管酶系统 (RAS) 为喘和COPD等肺部疾病提供了潜在的治疗方法. 虽然抑制某些RAS成分是有希望的,但需要进一步的研究来理解新的途径,并验证在人类临床试验中的发现.
科学领域:
- 肺部医学 肺部医学
- 心血管研究研究心血管研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 氨酸-血管氨系统 (RAS) 对于血压调节至关重要.
- RAS失调与炎症,氧化应激和肺部疾病如喘,COPD,IPF和ALI中的纤维化有关.
- 准RAS组件为呼吸道疾病提供了潜在的治疗策略.
研究的目的:
- 提供RAS的最新概述.
- 审查和分析针对针对RAS组件的最新研究,以治疗呼吸系统疾病.
- 突出RAS向治疗肺部疾病的治疗潜力和当前局限性.
主要方法:
- 在呼吸道疾病中对RAS进行实验和临床研究的汇编和分析.
- 对针对各种RAS组件 (例如,ACE,AT1R,ACE2,AT2R,Mas受体) 的药理干预措施的审查.
- 评估新出现的途径,如阿拉曼丁/MRGPRD.
主要成果:
- 在临床前和临床环境中,抑制促炎性RAS轴 (renin,ACE,Ang II,AT1R) 和激活保护轴 (ACE2,AT2R,Ang (1-7),Mas) 的有效性各不相同.
- 阿拉曼丁/MRGPRD途径显示出治疗的前景.
- 了解RAS连接体-受体相互作用和信号通路需要进一步阐明.
结论:
- 准RAS是治疗呼吸系统疾病的一个有希望的途径.
- 对一些RAS向分子的临床前发现是有希望的,但需要更强大的临床验证.
- 未来的研究应该优先考虑基于RAS的肺部疾病药物开发的转化人类研究.
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