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相关概念视频

Chest Physiotherapy01:24

Chest Physiotherapy

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Chest Physiotherapy (CPT) is a therapeutic technique used in respiratory care to improve ventilation, clear bronchial secretions, and enhance the efficiency of respiratory muscles. This therapy includes three primary procedures: postural drainage, percussion, and vibration. It can be performed on spontaneously breathing patients and those who are intubated and mechanically ventilated.
Purpose
CPT is primarily used for patients with excessive bronchial secretions who have difficulty clearing...
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Endoscopic Studies I: Bronchoscopy and Thoracoscopy01:30

Endoscopic Studies I: Bronchoscopy and Thoracoscopy

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Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
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Other Pulmonary Disorders01:17

Other Pulmonary Disorders

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
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COPD: Management Using Bronchodilators and Corticosteroids01:26

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Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
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Updated: Jul 20, 2025

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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肺部疾病的鼻疗法.

Peter J Barnes1

  • 1National Heart & Lung Institute, Imperial College London, United Kingdom.

Advances in pharmacology (San Diego, Calif.)
|July 31, 2023
PubMed
概括
此摘要是机器生成的。

细胞衰老在COPD和IPF等疾病中加速肺衰老. 针对衰老细胞的老年疗法在治疗这些疾病和降低死亡率方面表现有前途.

关键词:
慢性阻塞性肺病是一种慢性阻塞性肺病.异形性肺纤维化症 异形性肺纤维化症这是一个微型RNA.与衰老相关的分泌表现型这是一种老年分析.参静性 参静性 参静性在Sirtuin,我们可以看到.

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科学领域:

  • 肺部病理学 肺部病理学
  • 细胞生物学 细胞生物学
  • 老年学是一门学科.

背景情况:

  • 慢性肺病,包括COPD和IPF,表现出加速的肺衰老.
  • 细胞衰老,以衰老细胞的积累为特征,有助于疾病的进展.
  • 衰老细胞释放炎症因子 (SASP),加剧组织损伤和衰老.

研究的目的:

  • 探索老年疗法作为慢性肺部疾病的治疗方法.
  • 为了研究抑制衰老的药物 (衰老药物) 或消除衰老细胞 (衰老药物).

主要方法:

  • 对针对细胞衰老的现有和新兴药物的审查.
  • 鉴定 senostatics,包括PI3K-mTOR抑制剂,微RNA对抗体和抗氧化剂.
  • 在衰老细胞中诱导亡的老化剂的鉴定.

主要成果:

  • 老年疗法提供了一个潜在的策略来治疗COPD和IPF的潜在机制.
  • 抗衰老药可以抑制由氧化应激驱动的衰老发展.
  • 老化剂可以选择性地消除老化的细胞.

结论:

  • 准细胞衰老有望减少慢性肺部疾病的疾病进展和死亡率.
  • 目前正在进行临床试验,研究慢性肺部疾病中的老年疗法.