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手术前的激素刺激;它是否会增加手术后的并发症?
Mohamed Fawzy1, Marios Marcou1, Michael Sennert2
1Hypospadias Center, Pediatric Surgery Department, Sana Klinikum Offenbach, Frankfurt, Germany; Friedrich-Alexander-University Erlangen-Nuernberg, Erlangen, Germany.
Journal of pediatric urology
|July 31, 2023
概括
在手术前的激素刺激 (PHS) 显著增加了小腺的70%的低腺患者的小腺大小. 这种治疗没有导致更多的术后并发症,为手术结果提供了潜在的好处.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 手术创新 在外科创新.
- 内分泌学 在内分泌学.
背景情况:
- 缺,特别是带有和小子的近端形式,在外科手术方面具有挑战.
- 腺大小是影响手术结果的关键因素,在hypospadias修复.
- 关于手术前激素刺激 (PHS) 在这个特定的患者群体中增大腺的疗效的数据有限.
研究的目的:
- 为了评估PHS对近端低度和小度的儿童的角尺寸的影响.
- 确定PHS是否与术后并发症风险增加有关.
主要方法:
- 一项追溯的队列研究,包括101名近端低和小子 (≤12毫米) 的患者,他们正在进行两阶段的修复.
- 患者被分为两组:A组 (没有PHS) 和B组 (在第二阶段前1-2个月接受PHS).
- 在B组的PHS前后,在全身麻醉下客观地测量了腺尺寸 (长度和宽度).
主要成果:
- PHS导致长度 (p=0.042) 和宽度 (p=0.011) 在统计学上显著增加.
- 在接受PHS治疗的患者中,大约70%的患者经历了平均子宽度增加2.78mm.
- 在PHS和非PHS组之间没有观察到术后并发症率的显著差异 (p=0.556).
结论:
- 在大多数患有低度和小度的患者中,PHS有效地增加了子的大小.
- 可以安全地使用PHS,而不会增加手术并发症的风险.
- 在某些情况下,这种方法可以改善手术治疗的结果,以修复hypospadias.
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